| CAS No.: | 58186-27-9 |
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| Formula: | C19h30o5 |
| EINECS: | / |
| Type: | Cosmetic Raw Materials |
| Appearance: | Powder |
| Quality: | Technical |
| Samples: |
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| Customization: |
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Idebenone powder is a highly lipophilic compound that can also be dissolved by heating with an appropriate amount of grape seed oil. It is structurally similar to coenzyme Q10. As a highly effective antioxidant, it has cosmetic effects such as scavenging free radicals, inhibiting lipid peroxidation, inhibiting inflammation, inhibiting DNA damage, photoprotection, reducing pigmentation, improving fine lines, wrinkles and age spots. Currently, idebenone has been used in cosmetic formulations. However, considering its irritation and poor stability, further research on idebenone microemulsion is needed to make it more effective. Safely used in cosmetics. Idebenone is an organic compound with the molecular formula C19H30O5. It is yellow crystal or crystalline powder and odorless. Extremely difficult to dissolve in water, extremely soluble
Used in cosmetic formulations to scavenge free radicals and inhibit lipids
It has cosmetic functions such as plasma peroxidation, inhibition of inflammation, inhibition of DNA damage, photoprotection, and reduction of pigmentation.
Idebenone powder Bulk is an analogue of coenzyme Q10. Coenzyme Q is a fat-soluble quinone compound widely present in organisms and has the ability to promote oxidative phosphorylation reactions.
function to respond and protect the structural integrity of biofilms. Different sources of coenzyme Q have different numbers of isopentenyl units in their side chains. Humans and mammals are
10 units of isopentene, hence the name Coenzyme Q10. Coenzyme Q plays an important role in proton translocation and electron transfer in the respiratory chain in the body. It is a key component of cellular respiration.
And activator of cell metabolism, it is also an important antioxidant and non-specific immune enhancer.
1. Excellent free radical scavenger
Idebenone Powder has strong free scavenging ability among several common antioxidants. At the same concentration, idebenone has a similar ability to scavenge DPPH and AAPH as water-soluble vitamin E. Its ability to scavenge ABTS free radicals, tyrosine free radicals and peroxynitrite anions is 50 times that of water-soluble vitamin E. %. Idebenone, ascorbic acid and vitamin E can effectively eliminate free radicals at lower concentrations (10nmol/L). Coenzyme Q10 and kinetin need to be at concentrations of 100nmol/L and 1000nmol/L respectively to show their ability to scavenge free radicals.
2. Inhibit lipid peroxidation
Compared with ascorbic acid (>20mol/L), a-tocopherol (100rtmol/L), and glutathione (50tzmol/L), low concentration of idebenone (10Fmol/L) showed stronger antioxidant It can effectively inhibit the formation of lipid peroxides.
3. Inhibit inflammation and repair cutin
The Caspase (caspase) family is an inflammatory process and plays a very important role in mediating apoptosis, of which Caspase-3 is an important one. In the experiment, 0.5t,mol/L diethyl maleate and 0.1Fmol/L were used to activate Caspase-3 respectively, thus reflecting the degree of cell apoptosis. Studies have shown that 0.5~mol/L idebenone can significantly reduce the degree of apoptosis induced by diethyl maleate and , thereby inhibiting the occurrence of inflammation and improving tissue repair capabilities.
4. Prevent and treat DNA damage
Studies have shown that with sufficient UVB irradiation, the production of photoproducts in keratinocytes without any antioxidants is 53%, the production of photoproducts with idebenone is 23%, and the photoinhibition rate is 43%, while vitamin C, agonist The photoproduct inhibition rates of coenzyme, coenzyme Q10 and alpha-lipoic acid were 36%, 36%, 4% and 0% respectively. Idebenone significantly reduces UVB damage to DNA.
5. Inhibit light damage
The study found that when UVB was used to irradiate skin that had been coated with antioxidants, the sunburn cells of the skin coated with 0.5 idebenone were reduced by 38% compared to the blank, while vitamin E, kinetin, coenzyme Q10 and alpha-lipoic acid were respectively Reductions of 30%, 20%, 10%, 9% and 0%. It can be seen that idebenone has the most significant effect in inhibiting photodamage.
1. Excellent free radical scavenger
Idebenone Powder has strong free scavenging ability among several common antioxidants. At the same concentration, idebenone has a similar ability to scavenge DPPH and AAPH as water-soluble vitamin E. Its ability to scavenge ABTS free radicals, tyrosine free radicals and peroxynitrite anions is 50 times that of water-soluble vitamin E. %. Idebenone, ascorbic acid and vitamin E can effectively eliminate free radicals at lower concentrations (10nmol/L). Coenzyme Q10 and kinetin need to be at concentrations of 100nmol/L and 1000nmol/L respectively to show their ability to scavenge free radicals.
2. Inhibit lipid peroxidation
Compared with ascorbic acid (>20mol/L), a-tocopherol (100rtmol/L), and glutathione (50tzmol/L), low concentration of idebenone (10Fmol/L) showed stronger antioxidant It can effectively inhibit the formation of lipid peroxides.
3. Inhibit inflammation and repair cutin
The Caspase (caspase) family is an inflammatory process and plays a very important role in mediating apoptosis, of which Caspase-3 is an important one. In the experiment, 0.5t,mol/L diethyl maleate and 0.1Fmol/L were used to activate Caspase-3 respectively, thus reflecting the degree of cell apoptosis. Studies have shown that 0.5~mol/L idebenone can significantly reduce the degree of apoptosis induced by diethyl maleate , thereby inhibiting the occurrence of inflammation and improving tissue repair capabilities.
4. Prevent and treat DNA damage
Studies have shown that with sufficient UVB irradiation, the production of photoproducts in keratinocytes without any antioxidants is 53%, the production of photoproducts with idebenone is 23%, and the photoinhibition rate is 43%, while vitamin C, agonist The photoproduct inhibition rates of coenzyme, coenzyme Q10 and alpha-lipoic acid were 36%, 36%, 4% and 0% respectively. Idebenone significantly reduces UVB damage to DNA.
5. Inhibit light damage
The study found that when UVB was used to irradiate skin that had been coated with antioxidants, the sunburn cells of the skin coated with 0.5 idebenone were reduced by 38% compared to the blank, while vitamin E, kinetin, coenzyme Q10 and alpha-lipoic acid were respectively Reductions of 30%, 20%, 10%, 9% and 0%. It can be seen that idebenone has the most significant effect in inhibiting photodamage.
6. Inhibit melanin production
The inhibitory effect of idebenone on melanin is positively correlated with its addition amount. High concentrations of idebenone have similar effects; after a certain dilution, the inhibitory effect on melanin disappears, while low concentrations of idebenone still show inhibitory effects.
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