| Certification: | ISO, FDA |
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| Assay Method: | HPLC, UV |
| Application Form: | Powder |
| Application: | Food, Health Care Products, Medicine |
| State: | Powder |
| Extract Source: | Apple Extract |
| Samples: |
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| Customization: |
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Phloretin, alias trihydroxy phenol 2,4,6-trihydroxy-3- (4-hydroxyphenyl) . Is a new foreign research and development out of a new natural skin whitening agent, mainly in apples, pears and other juicy fruit peel and root bark. Phloretin can be used in facial masks, skin care creams, lotions and serums. For the pearl white crystalline powder, soluble in ethanol and , almost not soluble in water.
| Product Name | Phloretin |
| Specification | 98% |
| CAS NO. | 60-82-2 |
| Test Method | HPLC |
| Molecular Formula | C15H14O5 |
| Molecular Weight | 274.27 |
1. A new effective natural whitening product with high security.No harm to human skin.
2. Great performance of reserve skin water.can absorb 4 or 5 times of water compare to its own weight.
3. Promote absorbing other functional substance consist in the prescription.
4. Antioxidation,clear away our bodys free radicals.The thickness ofantioxidation towards lipin is between(10-30)10-6.
5. Prevent glucide enter into the epidermis,restranin sebum to excessive secrete.Can treat excessive-secretion acne.
6. Restrain the activity of melanin cells,lessen all kinds of facial flecks,etc.
1. Applied in food field, it aslo can be used as food and beverage additives.
2. Applied in pharmaceutical field, It can Anti-cancer and Anti-tumor, benefit heart and liver protection.
3. Applied in cosmetic field, Phloretin is mainly used as antioxidant, preventing UV radiation.
Pharmacological research on phloretin and cosmetics:
| Pilot projects | Concentration | Effect description |
| Elimination of free radical DPPH | 32umol/L | Elimination rate:74.6% |
| Inhibition of lipid peroxidation | 13umol/L | Inhibition rate:53% |
| Cell culture phloretin promotes the production of type 4 collagen | 25ug/mL | Promotion rate: 201.6±20.6 (blank 100) |
| Protection of phloretin against apoptosis of keratinocyte layer under 1.0J/cm2 UVB irradiation | 400ug/mL | Protection rate: 51.3% v9.6% |
| Cell culture phloretin promotes the production of ceramide | 2umol/L | Promotion rate :164(blank 100) |
| Inhibition of tyrosinase activity | 0.05% | Inhibition rate: 82.2% |
| Inhibition of 5α-reductase activity | Semi inhibitory concentration IC50:84.3ug/mL | |
| Inhibition of metalloproteinase MMP-1 activity | 5umol/L | Inhibition rate: 78% |
| Inhibition of interleukin IL-4 production | Semi inhibitory concentration IC50:>30umol/L | |
| Inhibition of β-hexosaminidase activity | 100ug/mL | Inhibition rate: 93.5% |
| Inhibition of transepidermal water evaporation by coating with phloretin | 50umol/L | Inhibition rate :25%(compared with blank) |
Product usage & recommended dosage:
Phloretin is widely used in many types of cosmetics and care products such as facial masks, lotions, essence, creams, sunscreens, shampoos, and conditioners.
| Specification | Recommended dose |
| Phloretin 98% | 0.3%-2.0% |
Phloretin Reference Formula:
Toner:
| Ingredient | Content (%) | Ingredient | Content (%) |
| phloretin | 0.05 | Methyl paraben | 0.2 |
| Propylene Glycol | 4.5 | Ethyl Paraben | 0.02 |
| Ethanol | 3.0 | Refined water | Margin |
| Glycerin | 0.5 |
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