The cone snail is a venomous tropical marine mollusk and is said to be one of the 500 most venomous creatures in the world. Cono snails can produce polypeptide venom for predation and defense. Each conch venom of the conch family may contain up to 200 pharmacologically active ingredients. The cono peptides used in cosmetics are biologically simulated cono toxins that have been genetically sequenced and artificially Biomimetic synthesis preserves biological activity and efficacy while reducing most of the toxicity. The arginine/glutamine component in the ingredient list is conopeptide.
Cone snails, also known as cone snails, belong to the cone snail superfamily of the marine gastropod family Cone superfamily. This family also includes poisonous molluscs such as Talisidae and Asparagus family. There are more than 500 species of cones in the world.
Conus snails can secrete a special type of polypeptide venom through the venom tube, which is used for prey and defense. This polypeptide venom is a very biologically active peptide, composed of many small peptides, and has strong penetrating power. , high stability, and can achieve the ultimate relaxation and stretching effect on muscles. Reduce damage to fibroblasts and collagen, avoid excessive cross-linking of skin collagen, and protect the skin.
Conotide is known as "smear-based toxin" and "anti-wrinkle artifact". It has strong neurotoxicity. In the fields of neuroscience, drug development and other fields, conotide has been studied and applied in many fields. In the field of cosmetics, cosmetics based on conopeptides have also been developed to remove facial wrinkles due to their ability to inhibit muscle contraction.
Developed by a Swiss laboratory with a background in biotechnology and pharmaceutical research, it mimics a neurotoxin, Conotoxin Biological Action: A neural component that causes muscles to relax without paralyzing muscle activity. Its efficacy is similar to that of Botox. Helps relieve wrinkles in a shorter period of time.
Conotide is a highly folded peptide with strong penetration, high stability, and targeted muscle relaxation. Conotide specifically blocks voltage-dependent sodium ion channels, specifically those in muscles. Conotoxin actually simulates the peptide component of conotoxin, so it is also called "conotoxin peptide" in some places. As reflected in the ingredient list, it is actually called "arginine/lysine peptide".
The ingredient list of cosmetics shows arginine/lysine, the most popular anti-aging ingredients at the moment. The effect is very significant. It is called smear-type toxin. One application can last for 8 hours, and it will fade after long-term application. Fine lines and delay skin aging. There are not many representative products on the market, and they are now popular in beauty salons.
Conotoxin has a relatively small molecular weight and extremely high target selectivity for voltage-gated channels. As a gated regulator of sodium ion channels, it can block voltage-dependent sodium channels for a long time, thereby regulating skeletal muscle expression, thereby achieving muscle Relaxing effect and quick and immediate anti-wrinkle effect.
From a mechanism point of view, conopeptide can inhibit the signal transmission of muscle contraction at multiple targets, retaining only 5% of neuromuscular current conduction, effectively relaxing the muscles without "paralyzing" the muscles, so it can provide a very natural and instantaneous Effect. Let's go directly to the verification of clinical data! After the subjects used 3% concentration of conopeptide, fine lines under the eyes were significantly reduced. The effect is already very significant in a short period of time (15 minutes), with an effective rate of up to 90%, and the effect lasts for 12 hours.
Conopeptide Powder, known as the "wrinkle killer", can effectively inhibit muscle contraction and relax facial muscles, effectively removing wrinkles instantly.
Tests so far have not shown any cytotoxicity, skin irritation, allergy or eye irritation from conopeptides.
1. Conotoxins can be used in various anti-aging personal care products
2. Eye care: It can significantly remove eye wrinkles and crow's feet at the corners of the eyes.
3. Facial care: It can significantly remove wrinkles on the forehead caused by muscle contraction.
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