Cardamonin, a known 2′,4′-dihydroxy-6′-methoxychalcone, was identified as an inhibitor of melanocyte differentiation, among many other pharmacology activities. Cardamonin promoted degradation of intracellular β-catenin while suppressing melanogenesis by down-regulating the expression of MITF and tyrosinase, resulting in decreased melanin content. Furthermore, it was found that cardamonin promoted the degradation of β-catenin through a GSK-3β-independent mechanism, which suggested that Siah-dependent pathway and/or a PKCα-dependent pathway, rather than a GSK-3β-dependent pathway, may mediate intracellularb-catenin degradation by cardamonin.
1.Cardamom extract cardamonin powder can improve indigestion, relieve flatulence
2.Cardamom extract cardamonin powder used to stimulates the appetite and reduces nausea
3.Cardamom extract cardamonin powder with the function of treating motion sickness
4.Cardamom extract cardamonin powder can make the skin whitening
1. Cardamin can be used in the field of cosmetics as a raw material for whitening products
2. Cardamin can be used in the pharmaceutical field