| Prduct Name: |
S-Adenosyl-L-methionine disulfate tosylate |
| Specification: |
98%min |
| CAS: |
97540-22-2 |
| MF: |
C22H32N6O15S4 |
| MW: |
766.79 |
| Certificate: |
ISO |
S-Adenosyl-L-Methionine Disulfate P-Toluene-Sulfonate is the disulfate salt of the stable p-toluene-sulfonate
complex of s-adenosyl-L-methionine (SAMe) with chemopreventive activity. SAMe disulfate p-toluene-sulfonate undergoes hydrolytic conversion to its active compound SAMe within cells. Although the mechanism of action is largely unknown, SAMe attenuates experimental liver damage and prevents experimental hepatocarcinogenesis. In addition, SAMe may reduce mitochondrial cytochrome C release, caspase 3 activation, and poly(ADP-ribose) polymerase cleavage, and attenuate okadaic acid-mediated hepatocyte apoptosis in a dose-dependent manner. SAMe is an essential compound in cellular transmethylation reactions and a precursor of polyamine and glutathione synthesis in the liver; SAMe deficiency is associated with chronic liver disease-associated decreases in the activity of methionine adenosyltransferase 1A (MAT1A), the enzyme that catalyzes the production of SAMe as the first step in methionine catabolism.
S-Adenosyl-L-methionine (also called S-adenosyl methionine, S-adenosylmethionine, SAMe, or SAM-e in the United States or ademetionine in Europe, and also often abbreviated as SAM and AdoMet) is a chemical that is found naturally in the body. SAMe is sold in the United States as a dietary supplement.
S-Adenosyl-L-methionine, also referred to as SAM or SAM-e, is of great importance in living organisms .
SAM-e occurs naturally in the human body and is synthesized from methionine .
Any changes in the availability of S-Adenosyl-L-methionine in the body affects cellular function. Abnormalities in energy production often result in liver diseases and neurological disorders .
Therefore, SAM-e has been used orally to treat liver diseases, fibromyalgia, mood disorders such as depression and neurological disorders, dementia, and Alzheimer's disease .
1) S-Adenosyl-L-Methionine Improves Depression
Sometimes the use of a supplementary medicine, such as high-dose S-Adenosyl-L-methionine, along with antidepressant medication has
proven to be beneficial.
2) SAM-e Helps Treat Liver Disorders
SAM-e helps restore liver function in the presence of chronic liver diseases such as alcoholic and non-alcoholic cirrhosis as well
as cholestasis .
SAM-e also prevents or reverses liver toxicity due to drugs like Tylenol and steroids .
SAM-e reduced liver dysfunction in humans who had alcoholic cirrhosis over a two-year period.
3) SAM-e May Improve Brain Function
SAM-e is linked to the folate cycle and vitamin B12 energy production, which provide methyl groups required for SAM-e mediated
methylation reactions .
SAM-e inhibits the increase of progression of these Alzheimer's-like features and also improves spatial memory .
4) S-Adenosyl-L-Methionine May Treat Osteoarthritis
Osteoarthritis is associated with pain, stiffness and reduced range of motion in the body. SAM-e alleviates the discomfort
associated with osteoarthritis .
5) SAM-e Reduces Symptoms Associated with Sjögren's Syndrome and Fibromyalgia.
Adenosylmethionine p-toluenesulfonate disulfate is the main component of adenosylmethionine (SAMe), which is marketed as a food supplement whose main functions are anti-depressant, liver protection, and treatment of arthritis. SAMe has become a high-end special product popular in Europe and the United States. Dietary supplement products. 1. A good liver nutrient This product is beneficial to the rehabilitation of patients with acute and chronic liver diseases, primary biliary cirrhosis, drug-induced cholestasis, cholestasis of pregnancy, alcoholic liver and liver cancer. S-adenosylmethionine can also prevent liver damage caused by alcohol, drugs and cytokines; prevent liver damage caused by chronic active hepatitis and other factors.
2. Regulate mood and resist depression This product can effectively regulate emotions, improve depression and psychotic symptoms, improve the patient's mood, depressive mania, eliminate guilt and suicidal tendencies, and improve the patient's sluggish response symptoms, and will not produce the side effects of other drugs for treating depression. Such as dry mouth, bladder problems, gender disorders, dizziness, headache, drowsiness, nausea, insomnia, and decreased vision, etc., it rarely interacts with other drugs. SAMe is safe to use, even in large doses, it is not dangerous. It is especially safe for pregnant women and women in childbearing period. It has a significant improvement effect on migraine and postpartum depression. It is the gospel for patients who have taken some conventional depression drugs for a long time and are ineffective. Therefore, oral adenosylmethionine enteric-coated tablets are affectionately called "happy tablets".
3. Improve joint pain This product has the functions of anti-inflammatory, alleviating pain and tissue repair, and has significant effects on arthropathy. It has obvious effects of promoting cartilage formation and reducing joint pain, stiffness and swelling.
4. Improve insomnia SAMe is very important for the synthesis of anti-aging hormone (melatonin) that regulates the sleep and wake cycle. It can promote dopamine and serotonin neurotic metabolism and sensory functions in the brain, and relieve fatigue, anorexia, insomnia, and anxiety And other symptoms.
5. Adjuvant treatment of various chronic diseases, such as: Parkinson's disease, pancreatitis, Alzheimer's disease, etc. With age, the adenosylmethionine in the body will be greatly reduced, supplementing exogenous health food supplements-adenosylmethionine can protect the liver and liver; anti-depression; anti-aging; improve sleep; reduce joint pain; for Parkinson's Various diseases such as chronic diseases have the effect of adjuvant treatment. Suitable crowd: Gold-collar and white-collar people with high mental pressure and long-term sub-health status; people with poor sleep; people who frequently drink alcohol; patients with liver disease; patients with arthritis, etc.
Audited Supplier 
){kind=link}
){kind=link}